Implications for Extracellular Matrix Interactions With Human Lung Basal Stem Cells in Lung Development, Disease, and Airway Modeling

Implications for Extracellular Matrix Interactions With Human Lung Basal Stem Cells in Lung Development, Disease, and Airway Modeling

The extracellular matrix (ECM) is not simply a quiescent scaffold. This three-dimensional network of extracellular macromolecules provides structural, mechanical, and biochemical support for the cells of the lung. Throughout life, the ECM forms a critical component of the pulmonary stem cell niche....

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Bibliographic Details
Main Authors: Shana M. Busch, Zareeb Lorenzana, Amy L. Ryan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
airway modeling
chronic lung disease
cellular niche
extracellular matrix
basal stem cells
regeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.645858/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.645858/full

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