Evaluating the Immunogenicity of Protein Drugs by Applying In Vitro MHC Binding Data and the Immune Epitope Database and Analysis Resource

The immune system has evolved to become highly specialized in recognizing and responding to pathogens and foreign molecules. Specifically, the function of HLA class II is to ensure that a sufficient sample of peptides derived from foreign molecules is presented to T cells. This leads to an important...

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Bibliographic Details
Main Authors: Sinu Paul, Ravi V. Kolla, John Sidney, Daniela Weiskopf, Ward Fleri, Yohan Kim, Bjoern Peters, Alessandro Sette
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2013/467852