Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity

Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity

Background Dendritic cells (DCs) play a critical role in antitumor immunity, but the therapeutic efficacy of DC-mediated cancer vaccine remains low, partly due to unsustainable DC function in tumor antigen presentation. Thus, identifying drugs that could enhance DC-based antitumor immunity and uncov...

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Bibliographic Details
Main Authors: Penghui Zhou, Peng Huang, Lei Cui, Zining Wang, Feifei Xu, Hongxia Zhang, Wenhua Lu, Wenzhuo He, Xiaojuan Wang, Mengyun Li, Huanling Zhang, Wenjing Xiong, Chunyuan Xie, Yongxiang Liu, Jinyun Liu, Xiaofeng Frank Qin, Xiaojun Xia
Format: Article
Language:English
Published: BMJ Publishing Group 2021-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/5/e002155.full

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https://jitc.bmj.com/content/9/5/e002155.full

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