Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells

Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells

Abstract As a dynamic organelle, mitochondria continuously fuse and divide with adjacent mitochondria. Imbalance in mitochondria dynamics leads to their dysfunction, which implicated in neurodegenerative diseases. However, how mitochondria alteration and glucose defect contribute to pathogenesis of...

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Bibliographic Details
Main Authors: So Jung Park, Ji-Eun Bae, Doo Sin Jo, Joon Bum Kim, Na Yeon Park, Jianguo Fang, Yong-Keun Jung, Dong Gyu Jo, Dong-Hyung Cho
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Brain
Subjects:
Drp1
O-GlcNAcylation
Mitochondrial fission
Amyloid-beta
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s13041-020-00727-w

Internet

https://doi.org/10.1186/s13041-020-00727-w

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