Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia

Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia

<p>Abstract</p> <p>Background</p> <p>Hypoxia induces microglial activation which causes damage to the developing brain. Microglia derived inflammatory mediators may contribute to this process. Toll-like receptor 4 (TLR4) has been reported to induce microglial activation...

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Bibliographic Details
Main Authors: Yao Linli, Kan Enci Mary, Lu Jia, Hao Aijun, Dheen S Thameem, Kaur Charanjit, Ling Eng-Ang
Format: Article
Language:English
Published: BMC 2013-02-01
Series:Journal of Neuroinflammation
Subjects:
Toll-like receptor 4
Microglia
NF-κB
Hypoxia-inducible factor-1α
Hypoxia
Inflammation
Online Access:http://www.jneuroinflammation.com/content/10/1/23

Internet

http://www.jneuroinflammation.com/content/10/1/23

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