Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea

ABSTRACT Obstructive sleep apnea (OSA) is a common sleep‐disordered breathing disease that often leads to many comorbidities (e.g., cognitive dysfunction), which adversely affect the quality of life for patients with OSA. Thus far, the underlying mechanisms of this dysfunction remain unclear. Many s...

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Main Authors:	Tingting Ji, Xiaodan Li, Yue Qiu, Lin Mei, Xinbei Jia, Jun Tai, Yongli Guo, Jie Zhang, Shengcai Wang, Xin Ni
Format:	Article
Language:	English
Published:	Wiley 2021-03-01
Series:	Pediatric Investigation
Subjects:	Obstructive sleep apnea Cognitive dysfunction Neuropathological mechanisms
Online Access:	https://doi.org/10.1002/ped4.12247

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spelling	doaj-c67005b3b8704200987a36658a0dda912021-05-03T04:32:29ZengWileyPediatric Investigation2574-22722021-03-0151525710.1002/ped4.12247Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apneaTingting Ji0Xiaodan Li1Yue Qiu2Lin Mei3Xinbei Jia4Jun Tai5Yongli Guo6Jie Zhang7Shengcai Wang8Xin Ni9Department of Otolaryngology, Head and Neck Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Otolaryngology, Head and Neck Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Otolaryngology, Head and Neck Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Otolaryngology, Head and Neck Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Otolaryngology, Head and Neck Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Otorhinolaryngology Beijing Children’s Hospital Capital Institute of Pediatrics Beijing ChinaBeijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery Beijing Pediatric Research Institute Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Otolaryngology, Head and Neck Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Otolaryngology, Head and Neck Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Otolaryngology, Head and Neck Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaABSTRACT Obstructive sleep apnea (OSA) is a common sleep‐disordered breathing disease that often leads to many comorbidities (e.g., cognitive dysfunction), which adversely affect the quality of life for patients with OSA. Thus far, the underlying mechanisms of this dysfunction remain unclear. Many studies have focused on OSA‐related characteristics, including intermittent hypoxemia and sleep fragmentation. There is increasing emphasis on neuroimaging studies to explore underlying relationships between neuropathological changes and cognitive dysfunction. This article reviews recent research progress concerning cognitive dysfunction associated with OSA to reveal potential mechanisms that contribute to this dysfunction.https://doi.org/10.1002/ped4.12247Obstructive sleep apneaCognitive dysfunctionNeuropathological mechanisms
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tingting Ji Xiaodan Li Yue Qiu Lin Mei Xinbei Jia Jun Tai Yongli Guo Jie Zhang Shengcai Wang Xin Ni
spellingShingle	Tingting Ji Xiaodan Li Yue Qiu Lin Mei Xinbei Jia Jun Tai Yongli Guo Jie Zhang Shengcai Wang Xin Ni Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea Pediatric Investigation Obstructive sleep apnea Cognitive dysfunction Neuropathological mechanisms
author_facet	Tingting Ji Xiaodan Li Yue Qiu Lin Mei Xinbei Jia Jun Tai Yongli Guo Jie Zhang Shengcai Wang Xin Ni
author_sort	Tingting Ji
title	Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea
title_short	Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea
title_full	Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea
title_fullStr	Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea
title_full_unstemmed	Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea
title_sort	disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea
publisher	Wiley
series	Pediatric Investigation
issn	2574-2272
publishDate	2021-03-01
description	ABSTRACT Obstructive sleep apnea (OSA) is a common sleep‐disordered breathing disease that often leads to many comorbidities (e.g., cognitive dysfunction), which adversely affect the quality of life for patients with OSA. Thus far, the underlying mechanisms of this dysfunction remain unclear. Many studies have focused on OSA‐related characteristics, including intermittent hypoxemia and sleep fragmentation. There is increasing emphasis on neuroimaging studies to explore underlying relationships between neuropathological changes and cognitive dysfunction. This article reviews recent research progress concerning cognitive dysfunction associated with OSA to reveal potential mechanisms that contribute to this dysfunction.
topic	Obstructive sleep apnea Cognitive dysfunction Neuropathological mechanisms
url	https://doi.org/10.1002/ped4.12247
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Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea

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