Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors

Neuronal hyperexcitability is a phenomenon associated with early Alzheimer’s disease. The underlying mechanism is considered to involve excessive activation of glutamate receptors; however, the exact molecular pathway remains to be determined. Extracellular recording from the CA1 of hippocampal slic...

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Bibliographic Details
Main Authors: Edina Varga, Gábor Juhász, Zsolt Bozsó, Botond Penke, Lívia Fülöp, Viktor Szegedi
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2014/584314