Discovery and Characterization of a Novel MASTL Inhibitor MKI-2 Targeting MASTL-PP2A in Breast Cancer Cells and Oocytes

Discovery and Characterization of a Novel MASTL Inhibitor MKI-2 Targeting MASTL-PP2A in Breast Cancer Cells and Oocytes

Although microtubule-associated serine/threonine kinase-like (MASTL) is a promising target for selective anticancer treatment, MASTL inhibitors with nano range potency and antitumor efficacy have not been reported. Here, we report a novel potent and selective MASTL inhibitor MASTL kinase inhibitor-2...

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Bibliographic Details
Main Authors: Minsung Kang, Chijung Kim, Jiyeon Leem, Ye-hyun Kim, Young-ju Kwon, Yi Na Yoon, Chong Hak Chae, Jiyeon Ahn, Kwan-Young Jung, Jeong Su Oh, Jae-Sung Kim
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceuticals
Subjects:
MASTL
MASTL inhibitor
PP2A
antitumor activity
breast cancer
Online Access:https://www.mdpi.com/1424-8247/14/7/647

Internet

https://www.mdpi.com/1424-8247/14/7/647

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