Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective

The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses ligand-independent basal signaling activity (...

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Bibliographic Details
Main Authors: Nicolas Heyder, Gunnar Kleinau, Michal Szczepek, Dennis Kwiatkowski, David Speck, Lucia Soletto, José Miguel Cerdá-Reverter, Heiko Krude, Peter Kühnen, Heike Biebermann, Patrick Scheerer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Endocrinology
Subjects:
G-protein coupled receptor
melanocortin receptors
MC4R
MSH
AgRP
ACTH
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00515/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00515/full

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