Using an Adenosine Triphosphate Bioluminescent Assay to Determine Effective Antibiotic Combinations against Carbapenem-Resistant Gram Negative Bacteria within 24 Hours.

Using an Adenosine Triphosphate Bioluminescent Assay to Determine Effective Antibiotic Combinations against Carbapenem-Resistant Gram Negative Bacteria within 24 Hours.

Current in vitro combination testing methods involve enumeration by bacterial plating, which is labor-intensive and time-consuming. Measurement of bioluminescence, released when bacterial adenosine triphosphate binds to firefly luciferin-luciferase, has been proposed as a surrogate for bacterial cou...

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Bibliographic Details
Main Authors: Yiying Cai, Hui Leck, Tze Peng Lim, Jocelyn Teo, Winnie Lee, Li Yang Hsu, Tse Hsien Koh, Thuan Tong Tan, Thean-Yen Tan, Andrea Lay-Hoon Kwa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4603788?pdf=render

Internet

http://europepmc.org/articles/PMC4603788?pdf=render

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