Risk Stratification of Cytogenetically Normal Acute Myeloid Leukemia With Biallelic CEBPA Mutations Based on a Multi-Gene Panel and Nomogram Model

Risk Stratification of Cytogenetically Normal Acute Myeloid Leukemia With Biallelic CEBPA Mutations Based on a Multi-Gene Panel and Nomogram Model

BackgroundApproximately 30% of Chinese individuals with cytogenetically normal acute myeloid leukemia (CN-AML) have biallelic CEBPA (biCEBPA) mutations. The prognosis and optimal therapy for these patients are controversial in clinical practice.MethodsIn this study, we performed targeted region sequ...

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Bibliographic Details
Main Authors: Li-Xin Wu, Hao Jiang, Ying-Jun Chang, Ya-Lan Zhou, Jing Wang, Zi-Long Wang, Lei-Ming Cao, Jin-Lan Li, Qiu-Yu Sun, Shan-Bo Cao, Feng Lou, Tao Zhou, Li-Xia Liu, Cheng-Cheng Wang, Yu Wang, Qian Jiang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang, Guo-Rui Ruan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
acute myeloid leukemia
targeted region sequencing (TRS)
biCEBPA mutations
risk stratification
therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.706935/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.706935/full

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