A Bidirectional Neuromodulation Technology for Nerve Recording and Stimulation

• Main Authors: Jian Xu, Hongsun Guo, Anh Tuan Nguyen, Hubert Lim, Zhi Yang
• Format: Article
• Language: English
• Published: MDPI AG 2018-10-01
• Series: Micromachines
• Subjects: system-on-chip; neuromodulation; bidirectional; closed-loop; sciatic nerve; vagus nerve; precision medicine
• Online Access: https://www.mdpi.com/2072-666X/9/11/538

Electrical nerve recording and stimulation technologies are critically needed to monitor and modulate nerve activity to treat a variety of neurological diseases. However, current neuromodulation technologies presented in the literature or commercially available products cannot support simultaneous recording and stimulation on the same nerve. To solve this problem, a new bidirectional neuromodulation system-on-chip (SoC) is proposed in this paper, which includes a frequency-shaping neural recorder and a fully integrated neural stimulator with charge balancing capability. In addition, auxiliary circuits consisting of power management and data transmission circuits are designed to provide the necessary power supply for the SoC and the bidirectional data communication between the SoC and an external computer via a universal serial bus (USB) interface, respectively. To achieve sufficient low input noise for sensing nerve activity at a sub-10 <inline-formula> <math display="inline"> <semantics> <mi mathvariant="sans-serif">&#956;</mi> </semantics> </math> </inline-formula>V range, several noise reduction techniques are developed in the neural recorder. The designed SoC was fabricated in a 0.18 <inline-formula> <math display="inline"> <semantics> <mi mathvariant="sans-serif">&#956;</mi> </semantics> </math> </inline-formula>m high-voltage Bipolar CMOS DMOS (BCD) process technology that was described in a previous publication and it has been recently tested in animal experiments that demonstrate the proposed SoC is capable of achieving reliable and simultaneous electrical stimulation and recording on the same nerve.