Nicotine Modulates Cognitive Function in D-Galactose-Induced Senescence in Mice

Nicotine Modulates Cognitive Function in D-Galactose-Induced Senescence in Mice

Here, we tested the claim that nicotine attenuates the signs of brain dysfunction in the model of brain aging induced by D-galactose (DGal) in mice. We administered nicotine at doses of 0.1, 0.5 and 1 mg/kg by the subcutaneous (s.c.) or at 0.1 mg/kg by the intranasal (i.n.) routes in mice that had r...

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Bibliographic Details
Main Authors: Alireza Majdi, Saeed Sadigh-Eteghad, Mahnaz Talebi, Fereshteh Farajdokht, Marjan Erfani, Javad Mahmoudi, Albert Gjedde
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
aging
nicotine
learning and memory
oxidative stress
mitochondrial dysfunction
neurotrophic factors
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00194/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2018.00194/full

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