Biodistribution and Molecular Studies on Orally Administered Nanoparticle-AON Complexes Encapsulated with Alginate Aiming at Inducing Dystrophin Rescue in mdx Mice

Biodistribution and Molecular Studies on Orally Administered Nanoparticle-AON Complexes Encapsulated with Alginate Aiming at Inducing Dystrophin Rescue in mdx Mice

We have previously demonstrated that intraperitoneal injections of 2′-O-methyl-phosphorothioate (2′OMePS) antisense oligoribonucleotides adsorbed onto a cationic core-shell nanoparticles (NPs), termed ZM2, provoke dystrophin restoration in the muscles of mdx mice. The aim of the present work was to...

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Bibliographic Details
Main Authors: Maria Sofia Falzarano, Chiara Passarelli, Elena Bassi, Marina Fabris, Daniela Perrone, Patrizia Sabatelli, Nadir M. Maraldi, Silvia Donà, Rita Selvatici, Paolo Bonaldo, Katia Sparnacci, Michele Laus, Paola Braghetta, Paola Rimessi, Alessandra Ferlini
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/527418

Internet

http://dx.doi.org/10.1155/2013/527418

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