Urinary biopyrrins: A new marker of oxidative stress in psoriasis
Background: Psoriasis is a common chronic, relapsing, immune-mediated disease involving skin and joints of genetically predisposed individuals. Oxidative stress has been found to play many important roles in cellular damage and loss of function in a number of tissues and organs and is believed to co...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
Series: | Indian Journal of Dermatology |
Subjects: | |
Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=2;spage=169;epage=173;aulast=Bakry |
id |
doaj-c7e50ec89275412e8b8d476badf81b89 |
---|---|
record_format |
Article |
spelling |
doaj-c7e50ec89275412e8b8d476badf81b892020-11-24T23:43:16ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112016-01-0161216917310.4103/0019-5154.177756Urinary biopyrrins: A new marker of oxidative stress in psoriasisOla Ahmed BakrySally El HefnawyAlaa Hassan MarieeYara El GendyBackground: Psoriasis is a common chronic, relapsing, immune-mediated disease involving skin and joints of genetically predisposed individuals. Oxidative stress has been found to play many important roles in cellular damage and loss of function in a number of tissues and organs and is believed to contribute to the pathogenesis of a variety of diseases. Urinary biopyrrin levels have gained attention as an indicator of oxidative stress. Aim and Objective: To measure urinary biopyrrins excretion as a marker of oxidative stress in psoriasis. Patients and Methods: This case–control study was carried out on 85 subjects; 55 cases with chronic plaque psoriasis and 30 age, gender and body mass index-matched normal subjects as a control group. Urinary biopyrrin levels were measured using enzyme immunoassay. Results: There was a highly significant difference between cases and controls regarding urinary biopyrrins level (P < 0.001). There was significant positive correlation between biopyrrins level and both the age of cases (r = 0.28, P = 0.01) and psoriasis area and severity index score (r = 0.99, P < 0.001). Conclusion: Urinary biopyrrins are increased in patients with psoriasis, and the level is correlated with disease severity. Further large-scale studies involving different ages and different clinical varieties of the disease are needed to expand and validate current findings. The clinical usefulness of antioxidants in psoriasis treatment needs to be evaluated in future research. Furthermore, the value of biopyrrins as biomarkers for monitoring response to therapy needs to be evaluated.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=2;spage=169;epage=173;aulast=BakryBiopyrrinsenzyme immunoassayoxidative stresspsoriasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ola Ahmed Bakry Sally El Hefnawy Alaa Hassan Mariee Yara El Gendy |
spellingShingle |
Ola Ahmed Bakry Sally El Hefnawy Alaa Hassan Mariee Yara El Gendy Urinary biopyrrins: A new marker of oxidative stress in psoriasis Indian Journal of Dermatology Biopyrrins enzyme immunoassay oxidative stress psoriasis |
author_facet |
Ola Ahmed Bakry Sally El Hefnawy Alaa Hassan Mariee Yara El Gendy |
author_sort |
Ola Ahmed Bakry |
title |
Urinary biopyrrins: A new marker of oxidative stress in psoriasis |
title_short |
Urinary biopyrrins: A new marker of oxidative stress in psoriasis |
title_full |
Urinary biopyrrins: A new marker of oxidative stress in psoriasis |
title_fullStr |
Urinary biopyrrins: A new marker of oxidative stress in psoriasis |
title_full_unstemmed |
Urinary biopyrrins: A new marker of oxidative stress in psoriasis |
title_sort |
urinary biopyrrins: a new marker of oxidative stress in psoriasis |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Dermatology |
issn |
0019-5154 1998-3611 |
publishDate |
2016-01-01 |
description |
Background: Psoriasis is a common chronic, relapsing, immune-mediated disease involving skin and joints of genetically predisposed individuals. Oxidative stress has been found to play many important roles in cellular damage and loss of function in a number of tissues and organs and is believed to contribute to the pathogenesis of a variety of diseases. Urinary biopyrrin levels have gained attention as an indicator of oxidative stress. Aim and Objective: To measure urinary biopyrrins excretion as a marker of oxidative stress in psoriasis. Patients and Methods: This case–control study was carried out on 85 subjects; 55 cases with chronic plaque psoriasis and 30 age, gender and body mass index-matched normal subjects as a control group. Urinary biopyrrin levels were measured using enzyme immunoassay. Results: There was a highly significant difference between cases and controls regarding urinary biopyrrins level (P < 0.001). There was significant positive correlation between biopyrrins level and both the age of cases (r = 0.28, P = 0.01) and psoriasis area and severity index score (r = 0.99, P < 0.001). Conclusion: Urinary biopyrrins are increased in patients with psoriasis, and the level is correlated with disease severity. Further large-scale studies involving different ages and different clinical varieties of the disease are needed to expand and validate current findings. The clinical usefulness of antioxidants in psoriasis treatment needs to be evaluated in future research. Furthermore, the value of biopyrrins as biomarkers for monitoring response to therapy needs to be evaluated. |
topic |
Biopyrrins enzyme immunoassay oxidative stress psoriasis |
url |
http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=2;spage=169;epage=173;aulast=Bakry |
work_keys_str_mv |
AT olaahmedbakry urinarybiopyrrinsanewmarkerofoxidativestressinpsoriasis AT sallyelhefnawy urinarybiopyrrinsanewmarkerofoxidativestressinpsoriasis AT alaahassanmariee urinarybiopyrrinsanewmarkerofoxidativestressinpsoriasis AT yaraelgendy urinarybiopyrrinsanewmarkerofoxidativestressinpsoriasis |
_version_ |
1725502332459810816 |