Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

Antimalarial drug resistance has historically arisen through convergent de novo mutations in Plasmodium falciparum parasite populations in Southeast Asia and South America. For the past decade in Southeast Asia, artemisinins, the core component of first-line antimalarial therapies, have experienced...

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Bibliographic Details
Main Authors: Luana C Mathieu, Horace Cox, Angela M Early, Sachel Mok, Yassamine Lazrek, Jeanne-Celeste Paquet, Maria-Paz Ade, Naomi W Lucchi, Quacy Grant, Venkatachalam Udhayakumar, Jean SF Alexandre, Magalie Demar, Pascal Ringwald, Daniel E Neafsey, David A Fidock, Lise Musset
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
Guyana
artemisinin resistance
evolution
kelch 13
South America
malaria
Online Access:https://elifesciences.org/articles/51015

Internet

https://elifesciences.org/articles/51015

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