Robust activation of microhomology-mediated end joining for precision gene editing applications.

Robust activation of microhomology-mediated end joining for precision gene editing applications.

One key problem in precision genome editing is the unpredictable plurality of sequence outcomes at the site of targeted DNA double stranded breaks (DSBs). This is due to the typical activation of the versatile Non-homologous End Joining (NHEJ) pathway. Such unpredictability limits the utility of som...

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Bibliographic Details
Main Authors: Hirotaka Ata, Thomas L Ekstrom, Gabriel Martínez-Gálvez, Carla M Mann, Alexey V Dvornikov, Kyle J Schaefbauer, Alvin C Ma, Drena Dobbs, Karl J Clark, Stephen C Ekker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6152997?pdf=render

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http://europepmc.org/articles/PMC6152997?pdf=render

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