National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990

Breast cancer is the most common cancer among women, causing considerable burden and mortality. Demographic and lifestyle transitions in low and low-middle income countries have given rise to its increased incidence. The successful management of cancer relies on evidence-based policies taking into a...

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Main Authors: Bahar Ataeinia, Sahar Saeedi Moghaddam, Mahsima Shabani, Kimiya Gohari, Ali Sheidaei, Nazila Rezaei, Shohreh Naderimagham, Erfan Ghasemi, Mahtab Rouhifard Khalilabad, Shahin Roshani, Yosef Farzi, Farshad Farzadfar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.561376/full
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author Bahar Ataeinia
Bahar Ataeinia
Sahar Saeedi Moghaddam
Mahsima Shabani
Mahsima Shabani
Kimiya Gohari
Ali Sheidaei
Nazila Rezaei
Shohreh Naderimagham
Erfan Ghasemi
Mahtab Rouhifard Khalilabad
Mahtab Rouhifard Khalilabad
Shahin Roshani
Shahin Roshani
Yosef Farzi
Farshad Farzadfar
Farshad Farzadfar
spellingShingle Bahar Ataeinia
Bahar Ataeinia
Sahar Saeedi Moghaddam
Mahsima Shabani
Mahsima Shabani
Kimiya Gohari
Ali Sheidaei
Nazila Rezaei
Shohreh Naderimagham
Erfan Ghasemi
Mahtab Rouhifard Khalilabad
Mahtab Rouhifard Khalilabad
Shahin Roshani
Shahin Roshani
Yosef Farzi
Farshad Farzadfar
Farshad Farzadfar
National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990
Frontiers in Oncology
age-period-cohort model
breast cancer
incidence
mortality
time trend
author_facet Bahar Ataeinia
Bahar Ataeinia
Sahar Saeedi Moghaddam
Mahsima Shabani
Mahsima Shabani
Kimiya Gohari
Ali Sheidaei
Nazila Rezaei
Shohreh Naderimagham
Erfan Ghasemi
Mahtab Rouhifard Khalilabad
Mahtab Rouhifard Khalilabad
Shahin Roshani
Shahin Roshani
Yosef Farzi
Farshad Farzadfar
Farshad Farzadfar
author_sort Bahar Ataeinia
title National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990
title_short National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990
title_full National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990
title_fullStr National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990
title_full_unstemmed National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990
title_sort national and subnational incidence, mortality, and years of life lost due to breast cancer in iran: trends and age-period-cohort analysis since 1990
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2021-03-01
description Breast cancer is the most common cancer among women, causing considerable burden and mortality. Demographic and lifestyle transitions in low and low-middle income countries have given rise to its increased incidence. The successful management of cancer relies on evidence-based policies taking into account national epidemiologic settings. We aimed to report the national and subnational trends of breast cancer incidence, mortality, years of life lost (YLL) and mortality to incidence ratio (MIR) since 1990. As part of the National and Subnational Burden of Diseases project, we estimated incidence, mortality and YLL of breast cancer by sex, age, province, and year using a two-stage spatio-temporal model, based on the primary dataset of national cancer and death registry. MIR was calculated as a quality of care indicator. Age-period-cohort analysis was used to distinguish the effects of these three collinear factors. A significant threefold increase in age-specific incidence at national and subnational levels along with a twofold extension of provincial disparity was observed. Although mortality has slightly decreased since 2000, a positive mortality annual percent change was detected in patients aged 25–34 years, leading to raised YLLs. A significant declining pattern of MIR and lower provincial MIR disparity was observed. We observed a secular increase of breast cancer incidence. Further evaluation of risk factors and developing national screening policies is recommended. A descending pattern of mortality, YLL and MIR at national and subnational levels reflects improved quality of care, even though mortality among younger age groups should be specifically addressed.
topic age-period-cohort model
breast cancer
incidence
mortality
time trend
url https://www.frontiersin.org/articles/10.3389/fonc.2021.561376/full
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spelling doaj-c87c3cf3ee844fa7b48ffc2da671f9d32021-03-25T07:53:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.561376561376National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990Bahar Ataeinia0Bahar Ataeinia1Sahar Saeedi Moghaddam2Mahsima Shabani3Mahsima Shabani4Kimiya Gohari5Ali Sheidaei6Nazila Rezaei7Shohreh Naderimagham8Erfan Ghasemi9Mahtab Rouhifard Khalilabad10Mahtab Rouhifard Khalilabad11Shahin Roshani12Shahin Roshani13Yosef Farzi14Farshad Farzadfar15Farshad Farzadfar16Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranCenter for Precision Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United StatesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranInternational Hematology/Oncology of Pediatrics Experts (IHOPE), Universal Scientific Education and Research Network (USERN), Tehran, IranDepartment of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IranBreast cancer is the most common cancer among women, causing considerable burden and mortality. Demographic and lifestyle transitions in low and low-middle income countries have given rise to its increased incidence. The successful management of cancer relies on evidence-based policies taking into account national epidemiologic settings. We aimed to report the national and subnational trends of breast cancer incidence, mortality, years of life lost (YLL) and mortality to incidence ratio (MIR) since 1990. As part of the National and Subnational Burden of Diseases project, we estimated incidence, mortality and YLL of breast cancer by sex, age, province, and year using a two-stage spatio-temporal model, based on the primary dataset of national cancer and death registry. MIR was calculated as a quality of care indicator. Age-period-cohort analysis was used to distinguish the effects of these three collinear factors. A significant threefold increase in age-specific incidence at national and subnational levels along with a twofold extension of provincial disparity was observed. Although mortality has slightly decreased since 2000, a positive mortality annual percent change was detected in patients aged 25–34 years, leading to raised YLLs. A significant declining pattern of MIR and lower provincial MIR disparity was observed. We observed a secular increase of breast cancer incidence. Further evaluation of risk factors and developing national screening policies is recommended. A descending pattern of mortality, YLL and MIR at national and subnational levels reflects improved quality of care, even though mortality among younger age groups should be specifically addressed.https://www.frontiersin.org/articles/10.3389/fonc.2021.561376/fullage-period-cohort modelbreast cancerincidencemortalitytime trend