High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice
In this study, the antifatigue potential of two sea cucumber peptides (SCP), with low hydrolysis degree (SCP-1) and high hydrolysis degree (SCP-2) derived from Acaudina leucoprocta was investigated. SCP-2 had a lower molecular weight, shorter peptide length, and higher proportion of identified seque...
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doaj-c8833ecb9e7c41a2a08ba9fdbbf6372c2021-08-12T04:33:31ZengElsevierJournal of Functional Foods1756-46462021-11-0186104677High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in miceQianqian Wang0Jinyuan Shi1Hao Zhong2 Abdullah3Jiachen Zhuang4Junhui Zhang5Jing Wang6Xi Zhang7Fengqin Feng8College of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaCollege of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaCollege of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaCollege of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaCollege of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaCollege of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaCollege of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China; Ningbo Research Institute, Zhejiang University, Ningbo 315100, ChinaCollege of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, 1076 Yuhua Road, Kunming 650500, China; Corresponding authors.College of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China; Corresponding authors.In this study, the antifatigue potential of two sea cucumber peptides (SCP), with low hydrolysis degree (SCP-1) and high hydrolysis degree (SCP-2) derived from Acaudina leucoprocta was investigated. SCP-2 had a lower molecular weight, shorter peptide length, and higher proportion of identified sequences related to branched chain amino acids than SCP-1. Both SCP-1 and SCP-2 significantly improved exercise performance and exerted antifatigue effects in comparison to the negative control group (NC). The mice group received SCP-2 treatment showed better antifatigue effects than that of SCP-1 by prolonging exhaustive swimming time, increasing forelimb grip strength, reducing metabolite accumulation, relieving muscle injury, enhancing muscle glycogen and energy metabolism. Besides, these two treatments significantly modulated the protein relative levels of oxidative stress and mitochondrial function by regulating the NRF2 and AMPK signaling pathways. Conclusively, the study’s findings suggested that SCP could possibly be used as a green functional ingredient to overcome fatigue.http://www.sciencedirect.com/science/article/pii/S1756464621003261Sea cucumber peptidesHydrolysis degreeAntifatigueOxidative stressMitochondrial function |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qianqian Wang Jinyuan Shi Hao Zhong Abdullah Jiachen Zhuang Junhui Zhang Jing Wang Xi Zhang Fengqin Feng |
spellingShingle |
Qianqian Wang Jinyuan Shi Hao Zhong Abdullah Jiachen Zhuang Junhui Zhang Jing Wang Xi Zhang Fengqin Feng High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice Journal of Functional Foods Sea cucumber peptides Hydrolysis degree Antifatigue Oxidative stress Mitochondrial function |
author_facet |
Qianqian Wang Jinyuan Shi Hao Zhong Abdullah Jiachen Zhuang Junhui Zhang Jing Wang Xi Zhang Fengqin Feng |
author_sort |
Qianqian Wang |
title |
High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice |
title_short |
High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice |
title_full |
High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice |
title_fullStr |
High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice |
title_full_unstemmed |
High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice |
title_sort |
high-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the nrf2 and ampk signaling pathways in mice |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2021-11-01 |
description |
In this study, the antifatigue potential of two sea cucumber peptides (SCP), with low hydrolysis degree (SCP-1) and high hydrolysis degree (SCP-2) derived from Acaudina leucoprocta was investigated. SCP-2 had a lower molecular weight, shorter peptide length, and higher proportion of identified sequences related to branched chain amino acids than SCP-1. Both SCP-1 and SCP-2 significantly improved exercise performance and exerted antifatigue effects in comparison to the negative control group (NC). The mice group received SCP-2 treatment showed better antifatigue effects than that of SCP-1 by prolonging exhaustive swimming time, increasing forelimb grip strength, reducing metabolite accumulation, relieving muscle injury, enhancing muscle glycogen and energy metabolism. Besides, these two treatments significantly modulated the protein relative levels of oxidative stress and mitochondrial function by regulating the NRF2 and AMPK signaling pathways. Conclusively, the study’s findings suggested that SCP could possibly be used as a green functional ingredient to overcome fatigue. |
topic |
Sea cucumber peptides Hydrolysis degree Antifatigue Oxidative stress Mitochondrial function |
url |
http://www.sciencedirect.com/science/article/pii/S1756464621003261 |
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