Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade

Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade

Oligodendrocytes are highly vulnerable to glutamate excitotoxicity, a central mechanism involved in tissue damage in Multiple Sclerosis (MS). Sustained activation of AMPA receptors in rat oligodendrocytes induces cytosolic calcium overload, mitochondrial depolarization, increase of reactive oxygen s...

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Bibliographic Details
Main Authors: Manuel Canedo-Antelo, Mari Paz Serrano, Andrea Manterola, Asier Ruiz, Francisco Llavero, Susana Mato, José Luis Zugaza, Fernando Pérez-Cerdá, Carlos Matute, María Victoria Sánchez-Gómez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
CK2
AMPA receptor
oligodendrocyte
apoptosis
mitogen-activated protein kinase (MAPK)
c-Jun N-terminal kinase (JNK)
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00333/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00333/full

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