Role of astrocytes in rhythmic motor activity
Abstract Rhythmic motor activities such as breathing, locomotion, tremor, or mastication are organized by groups of interconnected neurons. Most synapses in the central nervous system are in close apposition with processes belonging to astrocytes. Neurotransmitters released from neurons bind to rece...
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2021-09-01
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Online Access: | https://doi.org/10.14814/phy2.15029 |
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doaj-c8ba4e631b9e49519570add10f1aa4da2021-09-28T14:45:32ZengWileyPhysiological Reports2051-817X2021-09-01918n/an/a10.14814/phy2.15029Role of astrocytes in rhythmic motor activityAlexia Montalant0Eva M. M. Carlsen1Jean‐François Perrier2Department of Neuroscience Faculty of Health and Medical Sciences University of Copenhagen Copenhagen DenmarkDepartment of Neuroscience Faculty of Health and Medical Sciences University of Copenhagen Copenhagen DenmarkDepartment of Neuroscience Faculty of Health and Medical Sciences University of Copenhagen Copenhagen DenmarkAbstract Rhythmic motor activities such as breathing, locomotion, tremor, or mastication are organized by groups of interconnected neurons. Most synapses in the central nervous system are in close apposition with processes belonging to astrocytes. Neurotransmitters released from neurons bind to receptors expressed by astrocytes, activating a signaling pathway that leads to an increase in calcium concentration and the release of gliotransmitters that eventually modulate synaptic transmission. It is therefore likely that the activation of astrocytes impacts motor control. Here we review recent studies demonstrating that astrocytes inhibit, modulate, or trigger motor rhythmic behaviors.https://doi.org/10.14814/phy2.15029 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alexia Montalant Eva M. M. Carlsen Jean‐François Perrier |
spellingShingle |
Alexia Montalant Eva M. M. Carlsen Jean‐François Perrier Role of astrocytes in rhythmic motor activity Physiological Reports |
author_facet |
Alexia Montalant Eva M. M. Carlsen Jean‐François Perrier |
author_sort |
Alexia Montalant |
title |
Role of astrocytes in rhythmic motor activity |
title_short |
Role of astrocytes in rhythmic motor activity |
title_full |
Role of astrocytes in rhythmic motor activity |
title_fullStr |
Role of astrocytes in rhythmic motor activity |
title_full_unstemmed |
Role of astrocytes in rhythmic motor activity |
title_sort |
role of astrocytes in rhythmic motor activity |
publisher |
Wiley |
series |
Physiological Reports |
issn |
2051-817X |
publishDate |
2021-09-01 |
description |
Abstract Rhythmic motor activities such as breathing, locomotion, tremor, or mastication are organized by groups of interconnected neurons. Most synapses in the central nervous system are in close apposition with processes belonging to astrocytes. Neurotransmitters released from neurons bind to receptors expressed by astrocytes, activating a signaling pathway that leads to an increase in calcium concentration and the release of gliotransmitters that eventually modulate synaptic transmission. It is therefore likely that the activation of astrocytes impacts motor control. Here we review recent studies demonstrating that astrocytes inhibit, modulate, or trigger motor rhythmic behaviors. |
url |
https://doi.org/10.14814/phy2.15029 |
work_keys_str_mv |
AT alexiamontalant roleofastrocytesinrhythmicmotoractivity AT evammcarlsen roleofastrocytesinrhythmicmotoractivity AT jeanfrancoisperrier roleofastrocytesinrhythmicmotoractivity |
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