Optimization of a doxycycline hydroxypropyl-β-cyclodextrin inclusion complex based on computational modeling

To prepare a stable complex of doxycycline (Doxy) and hydroxypropy-β-cyclodextrin (HP-β-CD) for ophthalmic delivery, the optimum formulation and preparation conditions were investigated using response surface methodology (RSM), artificial neural network (ANN) and support vector machine (SVM) modelin...

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Bibliographic Details
Main Authors: Zhouhua Wang, Zixin He, Lei Zhang, Haohao Zhang, Meimei Zhang, Xinguo Wen, Guilan Quan, Xintian Huang, Xin Pan, Chuanbin Wu
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383513000142