Optimization of a doxycycline hydroxypropyl-β-cyclodextrin inclusion complex based on computational modeling
To prepare a stable complex of doxycycline (Doxy) and hydroxypropy-β-cyclodextrin (HP-β-CD) for ophthalmic delivery, the optimum formulation and preparation conditions were investigated using response surface methodology (RSM), artificial neural network (ANN) and support vector machine (SVM) modelin...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2013-04-01
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Series: | Acta Pharmaceutica Sinica B |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383513000142 |