Probing extracellular Sonic hedgehog in neurons

The bioactivity of Sonic hedgehog (Shh) depends on specific lipid modifications; a palmitate at its N-terminus and a cholesterol at its C-terminus. This dual-lipid modification makes Shh molecules lipophilic, which prevents them from diffusing freely in extracellular space. Multiple lines of evidenc...

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Bibliographic Details
Main Authors: Erez Eitan, Ronald S. Petralia, Ya-Xian Wang, Fred E. Indig, Mark P. Mattson, Pamela J. Yao
Format: Article
Published: The Company of Biologists 2016-08-01
Series:Biology Open
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