Probing extracellular Sonic hedgehog in neurons
The bioactivity of Sonic hedgehog (Shh) depends on specific lipid modifications; a palmitate at its N-terminus and a cholesterol at its C-terminus. This dual-lipid modification makes Shh molecules lipophilic, which prevents them from diffusing freely in extracellular space. Multiple lines of evidenc...
Main Authors: | Erez Eitan, Ronald S. Petralia, Ya-Xian Wang, Fred E. Indig, Mark P. Mattson, Pamela J. Yao |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2016-08-01
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Series: | Biology Open |
Subjects: | |
Online Access: | http://bio.biologists.org/content/5/8/1086 |
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