The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes

The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes

Neurodegenerative disorders are a major public health problem because of the high frequency of these diseases. Genome editing with the CRISPR/Cas9 system is making it possible to modify the sequence of genes linked to these disorders. We designed the KamiCas9 self-inactivating editing system to achi...

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Bibliographic Details
Main Authors: Nicolas Merienne, Gabriel Vachey, Lucie de Longprez, Cécile Meunier, Virginie Zimmer, Guillaume Perriard, Mathieu Canales, Amandine Mathias, Lucas Herrgott, Tim Beltraminelli, Axelle Maulet, Thomas Dequesne, Catherine Pythoud, Maria Rey, Luc Pellerin, Emmanuel Brouillet, Anselme L. Perrier, Renaud du Pasquier, Nicole Déglon
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
CRISPR/Cas9
gene editing
self-inactivating system
KamiCas9
neurodegenerative diseases
Huntington’s disease
lentiviral vectors
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312172

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http://www.sciencedirect.com/science/article/pii/S2211124717312172

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