Vulvar melanoma: report on eleven cases and review of the literature
CONTEXT AND OBJECTIVE: Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature. DESIGN AND SETTING: Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo. METHODS: Eleven patients with vulvar melanoma attended be...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Associação Paulista de Medicina
|
Series: | São Paulo Medical Journal |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802010000100008&lng=en&tlng=en |
id |
doaj-c97456caac35470f949fce6dc923f5ca |
---|---|
record_format |
Article |
spelling |
doaj-c97456caac35470f949fce6dc923f5ca2020-11-24T20:59:46ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94601281384110.1590/S1516-31802010000100008S1516-31802010000100008Vulvar melanoma: report on eleven cases and review of the literatureGlauco Baiocchi0João Pedreira Duprat1Rogerio Izar Neves2Elza Mieko Fukazawa3Gilles Landman4Gustavo Cardoso Guimarães5Leonardo Jacomo Valadares6Hospital A. C. CamargoHospital A. C. CamargoPennsylvania State UniversityHospital A. C. CamargoHospital A. C. CamargoHospital A. C. CamargoInstituto Brasileiro de Controle do CâncerCONTEXT AND OBJECTIVE: Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature. DESIGN AND SETTING: Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo. METHODS: Eleven patients with vulvar melanoma attended between January 1987 and December 2006 were reviewed regarding clinicopathological characteristics, surgical therapy and follow-up. RESULTS: The initial symptoms were vulvar lesions, pruritus, pain and bleeding. The median age was 64.8 years. The median depth of invasion was 3.08 mm. The staging ranged from IB to IIIC (American Joint Committee on Cancer, 2002). All the patients underwent vulvectomy. Two patients did not undergo primary elective lymphadenectomy. Bilateral inguinal lymphadenectomy was performed on five patients, and one had unilateral inguinal lymphadenectomy. Sentinel lymph node investigation was performed on three patients. Five patients had locoregional recurrence. Prolonged survival was only achieved in the absence of lymph node involvement. The median follow-up was 56 months. The median disease-free survival was 15 months and the median overall survival was 29 months. CONCLUSIONS: The prognosis for patients with vulvar melanoma is generally poor, with a high tendency towards regional and distant recurrence. Depth of invasion and lymph node involvement are the most important prognostic factors. In most cases, resection of the lesion with adequate margins may replace vulvectomy. Elective inguinal femoral lymphadenectomy remains the standard lymph node staging procedure. Sentinel lymph node investigation is feasible and should be performed by a multidisciplinary team with experience of this method.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802010000100008&lng=en&tlng=enVulvar neoplasmsLymphadenectomySentinel lymph node biopsyReview literature as topicMelanoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Glauco Baiocchi João Pedreira Duprat Rogerio Izar Neves Elza Mieko Fukazawa Gilles Landman Gustavo Cardoso Guimarães Leonardo Jacomo Valadares |
spellingShingle |
Glauco Baiocchi João Pedreira Duprat Rogerio Izar Neves Elza Mieko Fukazawa Gilles Landman Gustavo Cardoso Guimarães Leonardo Jacomo Valadares Vulvar melanoma: report on eleven cases and review of the literature São Paulo Medical Journal Vulvar neoplasms Lymphadenectomy Sentinel lymph node biopsy Review literature as topic Melanoma |
author_facet |
Glauco Baiocchi João Pedreira Duprat Rogerio Izar Neves Elza Mieko Fukazawa Gilles Landman Gustavo Cardoso Guimarães Leonardo Jacomo Valadares |
author_sort |
Glauco Baiocchi |
title |
Vulvar melanoma: report on eleven cases and review of the literature |
title_short |
Vulvar melanoma: report on eleven cases and review of the literature |
title_full |
Vulvar melanoma: report on eleven cases and review of the literature |
title_fullStr |
Vulvar melanoma: report on eleven cases and review of the literature |
title_full_unstemmed |
Vulvar melanoma: report on eleven cases and review of the literature |
title_sort |
vulvar melanoma: report on eleven cases and review of the literature |
publisher |
Associação Paulista de Medicina |
series |
São Paulo Medical Journal |
issn |
1806-9460 |
description |
CONTEXT AND OBJECTIVE: Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature. DESIGN AND SETTING: Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo. METHODS: Eleven patients with vulvar melanoma attended between January 1987 and December 2006 were reviewed regarding clinicopathological characteristics, surgical therapy and follow-up. RESULTS: The initial symptoms were vulvar lesions, pruritus, pain and bleeding. The median age was 64.8 years. The median depth of invasion was 3.08 mm. The staging ranged from IB to IIIC (American Joint Committee on Cancer, 2002). All the patients underwent vulvectomy. Two patients did not undergo primary elective lymphadenectomy. Bilateral inguinal lymphadenectomy was performed on five patients, and one had unilateral inguinal lymphadenectomy. Sentinel lymph node investigation was performed on three patients. Five patients had locoregional recurrence. Prolonged survival was only achieved in the absence of lymph node involvement. The median follow-up was 56 months. The median disease-free survival was 15 months and the median overall survival was 29 months. CONCLUSIONS: The prognosis for patients with vulvar melanoma is generally poor, with a high tendency towards regional and distant recurrence. Depth of invasion and lymph node involvement are the most important prognostic factors. In most cases, resection of the lesion with adequate margins may replace vulvectomy. Elective inguinal femoral lymphadenectomy remains the standard lymph node staging procedure. Sentinel lymph node investigation is feasible and should be performed by a multidisciplinary team with experience of this method. |
topic |
Vulvar neoplasms Lymphadenectomy Sentinel lymph node biopsy Review literature as topic Melanoma |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802010000100008&lng=en&tlng=en |
work_keys_str_mv |
AT glaucobaiocchi vulvarmelanomareportonelevencasesandreviewoftheliterature AT joaopedreiraduprat vulvarmelanomareportonelevencasesandreviewoftheliterature AT rogerioizarneves vulvarmelanomareportonelevencasesandreviewoftheliterature AT elzamiekofukazawa vulvarmelanomareportonelevencasesandreviewoftheliterature AT gilleslandman vulvarmelanomareportonelevencasesandreviewoftheliterature AT gustavocardosoguimaraes vulvarmelanomareportonelevencasesandreviewoftheliterature AT leonardojacomovaladares vulvarmelanomareportonelevencasesandreviewoftheliterature |
_version_ |
1716781565135028224 |