Bee Venom Soluble Phospholipase A2 Exerts Neuroprotective Effects in a Lipopolysaccharide-Induced Mouse Model of Alzheimer’s Disease via Inhibition of Nuclear Factor-Kappa B

Bee Venom Soluble Phospholipase A2 Exerts Neuroprotective Effects in a Lipopolysaccharide-Induced Mouse Model of Alzheimer’s Disease via Inhibition of Nuclear Factor-Kappa B

Neuroinflammation is important in the pathogenesis and development of Alzheimer’s disease (AD). In the AD brain, microglial activation and upregulation of pro-inflammatory mediators both induce amyloid beta (Aβ) accumulation. Regulatory T cells (Tregs) and nuclear factor-kappa B (NF-κB) signaling ha...

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Bibliographic Details
Main Authors: Hyeon Joo Ham, Ji Hye Han, Yong Sun Lee, Ki Cheon Kim, Jaesuk Yun, Shin Kook Kang, YangSu Park, Se Hyun Kim, Jin Tae Hong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
neuroinflammation
Alzheimer’s disease
NF-κB
regulatory T cells
bee venom phospholipase A2
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00287/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00287/full

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