Diffusion-weighted MRI: role in the differential diagnosis of breast lesions
'Purpose: 'To evaluate the diagnostic value of magnetic resonance diffusion-weighted imaging (DWI) using apparent diffusion coefficient (ADC) values to the characterization of breast lesions and differentiation of benign and malignant lesions. 'Materials and methods: 'Thirty-seve...
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doaj-c9ef92eb5a5b4e4d9ad3bb1891ebadba2020-11-24T22:08:15ZengUbiquity PressJournal of the Belgian Society of Radiology2514-82812014-07-0197421121610.5334/jbr-btr.8080Diffusion-weighted MRI: role in the differential diagnosis of breast lesionsC Altay0P Balci1S Altay2S Karasu3S Saydam4T Canda5O Dicle6Department of Radiology, Dokuz Eylul University, Faculty of Medicine, Izmir, TurkeyDepartment of Radiology, Dokuz Eylul University, Faculty of Medicine, Izmir, TurkeyDepartment of Radiology, Izmir Atatürk Research and Training Hospital, Izmir, TurkeyDepartment of Radiology, Izmir Atatürk Research and Training Hospital, Izmir, TurkeyDepartment of General Surgery, Dokuz Eylul University, Faculty of Medicine, Izmir, TurkeyDepartment of Pathology, Dokuz Eylul University, Faculty of Medicine, Izmir, TurkeyDepartment of Radiology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey'Purpose: 'To evaluate the diagnostic value of magnetic resonance diffusion-weighted imaging (DWI) using apparent diffusion coefficient (ADC) values to the characterization of breast lesions and differentiation of benign and malignant lesions. 'Materials and methods: 'Thirty-seven women (mean age, 38 years) with 37 enrolled in the study. DWI and ADC maps in the axial plane were obtained using a 1.5 Tesla MRI device. Mean ADC measurements were calculated among cysts, normal fibroglandular tissue, benign lesions and malignant lesions were evaluated. 'Results: 'Out of 37 women, 4 had normally breast MRI findings. The diagnosis of remaining 33 patients with 37 breast lesions were as follows; malign lesions (n = 23), benign lesions (n = 10) and simple breast cyst (n = 4). The ADC values were as follows ( in units of 10-3 mm2/s ): Normal fibroglandular tissue (range: 1.39-2.06; mean:1.61 ± 0.23), benign breast lesions (range: 1.09-1.76; mean: 1,47 ± 0.25), cyts (range: 2.27-2.46, mean: 2,37 ± 0.07) and malignant breast lesions (range: 0.78-1.26, mean: 0.96 ± 0.25). The mean ADC obtained from malignant breast lesions was statistically different from that observed in benign solid lesions (p < < 0.01) and normal fibroglandular breast tissue (p < 0.01). Furthermore, the mean ADC values of benign breast lesions was not statistically different from cyst (p = 0,01) and normal fibroglandular breast tissue (p = 0,01). A ADC value of 1.1 × 10-3 mm2/s as a treshold value provided differentiation for malign and benign lesions, with a sensitivity of 91.3% and a specificity of 85.7% compared with conventional breast MRI values. 'Conclusion: 'DWI with quantitative ADC measurements is a reliable tool for differentiation of benign and malignant breast lesions.https://www.jbsr.be/articles/80Breast neoplasmsMR |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
C Altay P Balci S Altay S Karasu S Saydam T Canda O Dicle |
spellingShingle |
C Altay P Balci S Altay S Karasu S Saydam T Canda O Dicle Diffusion-weighted MRI: role in the differential diagnosis of breast lesions Journal of the Belgian Society of Radiology Breast neoplasms MR |
author_facet |
C Altay P Balci S Altay S Karasu S Saydam T Canda O Dicle |
author_sort |
C Altay |
title |
Diffusion-weighted MRI: role in the differential diagnosis of breast lesions |
title_short |
Diffusion-weighted MRI: role in the differential diagnosis of breast lesions |
title_full |
Diffusion-weighted MRI: role in the differential diagnosis of breast lesions |
title_fullStr |
Diffusion-weighted MRI: role in the differential diagnosis of breast lesions |
title_full_unstemmed |
Diffusion-weighted MRI: role in the differential diagnosis of breast lesions |
title_sort |
diffusion-weighted mri: role in the differential diagnosis of breast lesions |
publisher |
Ubiquity Press |
series |
Journal of the Belgian Society of Radiology |
issn |
2514-8281 |
publishDate |
2014-07-01 |
description |
'Purpose: 'To evaluate the diagnostic value of magnetic resonance diffusion-weighted imaging (DWI) using apparent diffusion coefficient (ADC) values to the characterization of breast lesions and differentiation of benign and malignant lesions. 'Materials and methods: 'Thirty-seven women (mean age, 38 years) with 37 enrolled in the study. DWI and ADC maps in the axial plane were obtained using a 1.5 Tesla MRI device. Mean ADC measurements were calculated among cysts, normal fibroglandular tissue, benign lesions and malignant lesions were evaluated. 'Results: 'Out of 37 women, 4 had normally breast MRI findings. The diagnosis of remaining 33 patients with 37 breast lesions were as follows; malign lesions (n = 23), benign lesions (n = 10) and simple breast cyst (n = 4). The ADC values were as follows ( in units of 10-3 mm2/s ): Normal fibroglandular tissue (range: 1.39-2.06; mean:1.61 ± 0.23), benign breast lesions (range: 1.09-1.76; mean: 1,47 ± 0.25), cyts (range: 2.27-2.46, mean: 2,37 ± 0.07) and malignant breast lesions (range: 0.78-1.26, mean: 0.96 ± 0.25). The mean ADC obtained from malignant breast lesions was statistically different from that observed in benign solid lesions (p < < 0.01) and normal fibroglandular breast tissue (p < 0.01). Furthermore, the mean ADC values of benign breast lesions was not statistically different from cyst (p = 0,01) and normal fibroglandular breast tissue (p = 0,01). A ADC value of 1.1 × 10-3 mm2/s as a treshold value provided differentiation for malign and benign lesions, with a sensitivity of 91.3% and a specificity of 85.7% compared with conventional breast MRI values. 'Conclusion: 'DWI with quantitative ADC measurements is a reliable tool for differentiation of benign and malignant breast lesions. |
topic |
Breast neoplasms MR |
url |
https://www.jbsr.be/articles/80 |
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