ApoE4 induces synaptic and ERG impairments in the retina of young targeted replacement apoE4 mice.

The vertebrate retina, which is part of the central nervous system, is a window into the brain. The present study investigated the extent to which the retina can be used as a model for studying the pathological effects of apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheime...

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Bibliographic Details
Main Authors: Ran Antes, Raaya Ezra-Elia, Dov Weinberger, Arie Solomon, Ron Ofri, Daniel M Michaelson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3669199?pdf=render