APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups

APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups

Abstract Background Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of-function (LoF) variants in apolipoprotein C-III have been reported to reduce triglycerides (TG) and are cardioprotective in American Indians and Europeans. However, there is a l...

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Main Authors: Shiwali Goyal, Yosuke Tanigawa, Weihua Zhang, Jin-Fang Chai, Marcio Almeida, Xueling Sim, Megan Lerner, Juliane Chainakul, Jonathan Garcia Ramiu, Chanel Seraphin, Blair Apple, April Vaughan, James Muniu, Juan Peralta, Donna M. Lehman, Sarju Ralhan, Gurpreet S. Wander, Jai Rup Singh, Narinder K. Mehra, Evgeny Sidorov, Marvin D. Peyton, Piers R. Blackett, Joanne E. Curran, E. Shyong Tai, Rob van Dam, Ching-Yu Cheng, Ravindranath Duggirala, John Blangero, John C. Chambers, Charumathi Sabanayagam, Jaspal S. Kooner, Manuel A. Rivas, Christopher E. Aston, Dharambir K. Sanghera
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Lipids in Health and Disease
Subjects:
ApoC-III
Rare and common variants
Mendelian randomization
Triglyceride
Coronary artery disease risk
Asian Indians
Online Access:https://doi.org/10.1186/s12944-021-01531-8

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