Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice

Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice

Abstract Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema. Here we demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release o...

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Bibliographic Details
Main Authors: Mégane Nascimento, Aurélie Gombault, Norinne Lacerda-Queiroz, Corinne Panek, Florence Savigny, Malak Sbeity, Manon Bourinet, Marc Le Bert, Nicolas Riteau, Bernhard Ryffel, Valérie F. J. Quesniaux, Isabelle Couillin
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-51427-y

Internet

https://doi.org/10.1038/s41598-019-51427-y

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