Topically applicated curcumin/gelatin-blended nanofibrous mat inhibits pancreatic adenocarcinoma by increasing ROS production and endoplasmic reticulum stress mediated apoptosis

Topically applicated curcumin/gelatin-blended nanofibrous mat inhibits pancreatic adenocarcinoma by increasing ROS production and endoplasmic reticulum stress mediated apoptosis

Abstract Background Pancreatic adenocarcinoma (PDAC) is one of the most fatal malignancies. Surgical resection supplemented by chemotherapy remains the major therapeutic regimen, but with unavoidable resistance and systemic toxic reaction. Curcumin is a known safe natural compound that can effective...

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Bibliographic Details
Main Authors: Tao Cheng, Zhiheng Zhang, Hua Shen, Ziying Jian, Junsheng Li, Yujun Chen, Yi Shen, Xinyi Dai
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Nanobiotechnology
Subjects:
Curcumin
Nanofibrous mat (NM)
Pancreatic adenocarcinoma
Tumor suppression
Bioavailability
Online Access:http://link.springer.com/article/10.1186/s12951-020-00687-2

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http://link.springer.com/article/10.1186/s12951-020-00687-2

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