Systematic discovery of the functional impact of somatic genome alterations in individual tumors through tumor-specific causal inference.

Systematic discovery of the functional impact of somatic genome alterations in individual tumors through tumor-specific causal inference.

Cancer is mainly caused by somatic genome alterations (SGAs). Precision oncology involves identifying and targeting tumor-specific aberrations resulting from causative SGAs. We developed a novel tumor-specific computational framework that finds the likely causative SGAs in an individual tumor and es...

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Bibliographic Details
Main Authors: Chunhui Cai, Gregory F Cooper, Kevin N Lu, Xiaojun Ma, Shuping Xu, Zhenlong Zhao, Xueer Chen, Yifan Xue, Adrian V Lee, Nathan Clark, Vicky Chen, Songjian Lu, Lujia Chen, Liyue Yu, Harry S Hochheiser, Xia Jiang, Q Jane Wang, Xinghua Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-07-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007088

Internet

https://doi.org/10.1371/journal.pcbi.1007088

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