Non-viral reprogramming of human nucleus pulposus cells with FOXF1 via extracellular vesicle delivery: an in vitro and in vivo study

Non-viral reprogramming of human nucleus pulposus cells with FOXF1 via extracellular vesicle delivery: an in vitro and in vivo study

Intervertebral disc (IVD) degeneration is characterized by decreased cellularity and proteoglycan synthesis and increased inflammation, catabolism, and neural/vascular ingrowth. Regenerative methods for IVD degeneration are largely cell-therapy-based or involve viral vectors, which are associated wi...

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Bibliographic Details
Main Authors: S Tang, A Salazar-Puerta, J Richards, S Khan, JA Hoyland, D Gallego-Perez, B Walter, N Higuita-Castro, D Purmessur
Format: Article
Language:English
Published: AO Research Institute Davos 2021-01-01
Series:European Cells & Materials
Subjects:
intervertebral disc degeneration
low-back pain
cellular reprogramming
engineered extracellular vesicles
transcription factor
electroporation
foxf1
regeneration.
Online Access:https://www.ecmjournal.org/papers/vol041/pdf/v041a07.pdf

Internet

https://www.ecmjournal.org/papers/vol041/pdf/v041a07.pdf

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