Mechanisms by Which B Cells and Regulatory T Cells Influence Development of Murine Organ-Specific Autoimmune Diseases

Mechanisms by Which B Cells and Regulatory T Cells Influence Development of Murine Organ-Specific Autoimmune Diseases

Experiments with B cell-deficient (B−/−) mice indicate that a number of autoimmune diseases require B cells in addition to T cells for their development. Using B−/− Non-obese diabetic (NOD) and NOD.H-2h4 mice, we demonstrated that development of spontaneous autoimmune thyroiditis (SAT), Sjogren’s sy...

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Bibliographic Details
Main Authors: Jason S. Ellis, Helen Braley-Mullen
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Journal of Clinical Medicine
Subjects:
B cells
autoimmunity
regulatory T cells
effector T cells
APC
Online Access:http://www.mdpi.com/2077-0383/6/2/13

Internet

http://www.mdpi.com/2077-0383/6/2/13

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