Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer

Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer

Abstract Background APOBEC-driven mutagenesis and functional positive selection of mutated genes may synergistically drive the higher frequency of some hotspot driver mutations compared to other mutations within the same gene, as we reported for FGFR3 S249C. Only a few APOBEC-associated driver hotsp...

Full description

Bibliographic Details
Main Authors: Ming-Jun Shi, Xiang-Yu Meng, Jacqueline Fontugne, Chun-Long Chen, François Radvanyi, Isabelle Bernard-Pierrot
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Genome Medicine
Subjects:
Bladder cancer
APOBEC
Mutagenesis
Stem-loop
Driver mutation
Passenger mutation
Online Access:http://link.springer.com/article/10.1186/s13073-020-00781-y

Internet

http://link.springer.com/article/10.1186/s13073-020-00781-y

Similar Items