Inhibition of Cathepsin S Induces Mitochondrial Apoptosis in Glioblastoma Cell Lines Through Mitochondrial Stress and Autophagosome Accumulation

Inhibition of Cathepsin S Induces Mitochondrial Apoptosis in Glioblastoma Cell Lines Through Mitochondrial Stress and Autophagosome Accumulation

Cathepsin S (CTSS), a lysosomal cysteine protease, is overexpressed in various cancers, including glioblastoma (GB). A high level of CTSS is associated with tumor progression and poor outcome in GB. However, the underlying mechanisms of its role in the biological characteristics of G5B remain to be...

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Bibliographic Details
Main Authors: Maoxing Fei, Li Zhang, Handong Wang, Yihao Zhu, Wenhao Niu, Ting Tang, Yanling Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
cathepsin S
glioblastoma
autophagy
mitophagy
mitochondrial calcium uniporter
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.516746/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.516746/full

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