Single-Cell Genetic Analysis Using Automated Microfluidics to Resolve Somatic Mosaicism.

Single-Cell Genetic Analysis Using Automated Microfluidics to Resolve Somatic Mosaicism.

Somatic mosaicism occurs throughout normal development and contributes to numerous disease etiologies, including tumorigenesis and neurological disorders. Intratumor genetic heterogeneity is inherent to many cancers, creating challenges for effective treatments. Unfortunately, analysis of bulk DNA m...

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Bibliographic Details
Main Authors: Keith E Szulwach, Peilin Chen, Xiaohui Wang, Jing Wang, Lesley S Weaver, Michael L Gonzales, Gang Sun, Marc A Unger, Ramesh Ramakrishnan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4547741?pdf=render

Internet

http://europepmc.org/articles/PMC4547741?pdf=render

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