Th1-Polarized, Dengue Virus-Activated Human Mast Cells Induce Endothelial Transcriptional Activation and Permeability

Th1-Polarized, Dengue Virus-Activated Human Mast Cells Induce Endothelial Transcriptional Activation and Permeability

Dengue virus (DENV), an arbovirus, strongly activates mast cells (MCs), which are key immune cells for pathogen immune surveillance. In animal models, MCs promote clearance of local peripheral DENV infections but, conversely, also promote pathological vascular leakage when widely activated during sy...

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Bibliographic Details
Main Authors: Ayesa Syenina, Wilfried A. A. Saron, Cyril J. Jagaraj, Siham Bibi, Michel Arock, Duane J. Gubler, Abhay P. S. Rathore, Soman N. Abraham, Ashley L. St. John
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Viruses
Subjects:
dengue
mast cell
human
endothelial permeability
chymase
Online Access:https://www.mdpi.com/1999-4915/12/12/1379

Internet

https://www.mdpi.com/1999-4915/12/12/1379

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