Doxycycline and hydroxypropyl-β-cyclodextrin complex in poloxamer thermal sensitive hydrogel for ophthalmic delivery
The present study aimed to prepare a chemically and physically stable formulation of doxycycline (Doxy) in an in situ thermally sensitive hydrogel for ophthalmic delivery. An inclusion complex of Doxy and hydroxypropyl-β-cyclodextrin (HP-β-CD) was first developed to increase the stability of Doxy in...
Main Authors: | Zi-xin He, Zhou-hua Wang, Hao-hao Zhang, Xin Pan, Wen-ru Su, Dan Liang, Chuan-bin Wu |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2011-12-01
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Series: | Acta Pharmaceutica Sinica B |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383511000840 |
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