Metoclopramide-Induced Acute Dystonic Reactions May Be Associated With the CYP2D6 Poor Metabolizer Status and Pregnancy-Related Hormonal Changes

Metoclopramide-Induced Acute Dystonic Reactions May Be Associated With the CYP2D6 Poor Metabolizer Status and Pregnancy-Related Hormonal Changes

We report two cases of metoclopramide-induced acute dystonia in pregnant women and consider the role of genetic variation in the pathogenesis of the adverse effect. By whole-gene sequencing, we found that both women were CYP2D6 poor metabolizers. We theorize that CYP2D6 governs the risk of metoclopr...

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Bibliographic Details
Main Authors: Eng Wee Chua, Simon P. Harger, Martin A. Kennedy
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
metoclopramide
acute dystonia
CYP2D6
poor metabolizer
pregnancy
estrogen
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00931/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00931/full

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