Targeting Thioredoxin System with an Organosulfur Compound, Diallyl Trisulfide (DATS), Attenuates Progression and Metastasis of Triple-Negative Breast Cancer (TNBC)

Targeting Thioredoxin System with an Organosulfur Compound, Diallyl Trisulfide (DATS), Attenuates Progression and Metastasis of Triple-Negative Breast Cancer (TNBC)

Background/Aims: Metastasis is the leading cause resulting in high mortality in triple negative breast cancer (TNBC) patients. Cancer cells are skilled at utilizing thioredoxin (Trx) system as an efficient antioxidant system to counteract oxidative damage, facilitating the occurrence of metastasis....

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Bibliographic Details
Main Authors: Yuping Liu, Yang Zhao, Zhonghong Wei, Li Tao, Xiaobo Sheng, Siliang Wang, Jiao Chen, Junshan Ruan, Zhaoguo Liu, Yuzhu Cao, Yunlong Shan, Aiyun Wang, Wenxing Chen, Yin Lu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
DATS
Metastatic breast cancer
Oxidative stress
Thioredoxin system
Trx-1
Online Access:https://www.karger.com/Article/FullText/494874

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https://www.karger.com/Article/FullText/494874

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