High Dose Ascorbate Causes Both Genotoxic and Metabolic Stress in Glioma Cells

We have previously shown that exposure to high dose ascorbate causes double stranded breaks (DSBs) and a build-up in S-phase in glioblastoma (GBM) cell lines. Here we investigated whether or not this was due to genotoxic stress as well as metabolic stress generated by exposure to high dose ascorbate...

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Bibliographic Details
Main Authors: Maria Leticia Castro, Georgia M. Carson, Melanie J. McConnell, Patries M. Herst
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/6/3/58