Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children
Chronic exposure to minocycline, a commonly used anti-acne medication, results in a variety of autoimmune syndromes. Minocycline-induced vasculitis often associated with the presence of antinuclear antibody (ANA) and antineutrophil cytoplasmic antibody (ANCA) has been reported in Western literature,...
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Wolters Kluwer Medknow Publications
2021-01-01
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Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=2;spage=214;epage=216;aulast=Kapur |
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doaj-cda0cbfa18f0408fa6ae92e8072e18692021-07-07T10:50:42ZengWolters Kluwer Medknow PublicationsIndian Journal of Rheumatology0973-36980973-37012021-01-0116221421610.4103/injr.injr_33_20Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in childrenSunil KapurJitendra OswalChronic exposure to minocycline, a commonly used anti-acne medication, results in a variety of autoimmune syndromes. Minocycline-induced vasculitis often associated with the presence of antinuclear antibody (ANA) and antineutrophil cytoplasmic antibody (ANCA) has been reported in Western literature, mainly in adults. Herein, we report a rare case of a 15-year-old male child on minocycline treatment for 1 year, who presented with fever, skin rash, and polyarthralgia for 4 months. His erythrocyte sedimentation rate (ESR) level was elevated, ANA and myeloperoxidase ANCA were positive, and skin biopsy revealed leukocytoclastic vasculitis. Upon discontinuation of minocycline and prescribing a short course of oral steroids, all his symptoms resolved and ESR normalized within 2 weeks. The child remained asymptomatic with normal acute-phase reactants at 2-month follow-up. This outcome suggested that minocycline was the main cause of ANCA-associated vasculitis.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=2;spage=214;epage=216;aulast=Kapurantineutrophil cytoplasmic antibodiesdrug-induced vasculitisleukocytoclastic vasculitisminocycline |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sunil Kapur Jitendra Oswal |
spellingShingle |
Sunil Kapur Jitendra Oswal Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children Indian Journal of Rheumatology antineutrophil cytoplasmic antibodies drug-induced vasculitis leukocytoclastic vasculitis minocycline |
author_facet |
Sunil Kapur Jitendra Oswal |
author_sort |
Sunil Kapur |
title |
Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children |
title_short |
Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children |
title_full |
Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children |
title_fullStr |
Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children |
title_full_unstemmed |
Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children |
title_sort |
minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Rheumatology |
issn |
0973-3698 0973-3701 |
publishDate |
2021-01-01 |
description |
Chronic exposure to minocycline, a commonly used anti-acne medication, results in a variety of autoimmune syndromes. Minocycline-induced vasculitis often associated with the presence of antinuclear antibody (ANA) and antineutrophil cytoplasmic antibody (ANCA) has been reported in Western literature, mainly in adults. Herein, we report a rare case of a 15-year-old male child on minocycline treatment for 1 year, who presented with fever, skin rash, and polyarthralgia for 4 months. His erythrocyte sedimentation rate (ESR) level was elevated, ANA and myeloperoxidase ANCA were positive, and skin biopsy revealed leukocytoclastic vasculitis. Upon discontinuation of minocycline and prescribing a short course of oral steroids, all his symptoms resolved and ESR normalized within 2 weeks. The child remained asymptomatic with normal acute-phase reactants at 2-month follow-up. This outcome suggested that minocycline was the main cause of ANCA-associated vasculitis. |
topic |
antineutrophil cytoplasmic antibodies drug-induced vasculitis leukocytoclastic vasculitis minocycline |
url |
http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=2;spage=214;epage=216;aulast=Kapur |
work_keys_str_mv |
AT sunilkapur minocyclineinducedantineutrophilcytoplasmicantibodyassociatedvasculitisinchildren AT jitendraoswal minocyclineinducedantineutrophilcytoplasmicantibodyassociatedvasculitisinchildren |
_version_ |
1721316429418987520 |