Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children

Chronic exposure to minocycline, a commonly used anti-acne medication, results in a variety of autoimmune syndromes. Minocycline-induced vasculitis often associated with the presence of antinuclear antibody (ANA) and antineutrophil cytoplasmic antibody (ANCA) has been reported in Western literature,...

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Main Authors: Sunil Kapur, Jitendra Oswal
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Indian Journal of Rheumatology
Subjects:
Online Access:http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=2;spage=214;epage=216;aulast=Kapur
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spelling doaj-cda0cbfa18f0408fa6ae92e8072e18692021-07-07T10:50:42ZengWolters Kluwer Medknow PublicationsIndian Journal of Rheumatology0973-36980973-37012021-01-0116221421610.4103/injr.injr_33_20Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in childrenSunil KapurJitendra OswalChronic exposure to minocycline, a commonly used anti-acne medication, results in a variety of autoimmune syndromes. Minocycline-induced vasculitis often associated with the presence of antinuclear antibody (ANA) and antineutrophil cytoplasmic antibody (ANCA) has been reported in Western literature, mainly in adults. Herein, we report a rare case of a 15-year-old male child on minocycline treatment for 1 year, who presented with fever, skin rash, and polyarthralgia for 4 months. His erythrocyte sedimentation rate (ESR) level was elevated, ANA and myeloperoxidase ANCA were positive, and skin biopsy revealed leukocytoclastic vasculitis. Upon discontinuation of minocycline and prescribing a short course of oral steroids, all his symptoms resolved and ESR normalized within 2 weeks. The child remained asymptomatic with normal acute-phase reactants at 2-month follow-up. This outcome suggested that minocycline was the main cause of ANCA-associated vasculitis.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=2;spage=214;epage=216;aulast=Kapurantineutrophil cytoplasmic antibodiesdrug-induced vasculitisleukocytoclastic vasculitisminocycline
collection DOAJ
language English
format Article
sources DOAJ
author Sunil Kapur
Jitendra Oswal
spellingShingle Sunil Kapur
Jitendra Oswal
Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children
Indian Journal of Rheumatology
antineutrophil cytoplasmic antibodies
drug-induced vasculitis
leukocytoclastic vasculitis
minocycline
author_facet Sunil Kapur
Jitendra Oswal
author_sort Sunil Kapur
title Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children
title_short Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children
title_full Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children
title_fullStr Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children
title_full_unstemmed Minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children
title_sort minocycline-induced antineutrophil cytoplasmic antibody-associated vasculitis in children
publisher Wolters Kluwer Medknow Publications
series Indian Journal of Rheumatology
issn 0973-3698
0973-3701
publishDate 2021-01-01
description Chronic exposure to minocycline, a commonly used anti-acne medication, results in a variety of autoimmune syndromes. Minocycline-induced vasculitis often associated with the presence of antinuclear antibody (ANA) and antineutrophil cytoplasmic antibody (ANCA) has been reported in Western literature, mainly in adults. Herein, we report a rare case of a 15-year-old male child on minocycline treatment for 1 year, who presented with fever, skin rash, and polyarthralgia for 4 months. His erythrocyte sedimentation rate (ESR) level was elevated, ANA and myeloperoxidase ANCA were positive, and skin biopsy revealed leukocytoclastic vasculitis. Upon discontinuation of minocycline and prescribing a short course of oral steroids, all his symptoms resolved and ESR normalized within 2 weeks. The child remained asymptomatic with normal acute-phase reactants at 2-month follow-up. This outcome suggested that minocycline was the main cause of ANCA-associated vasculitis.
topic antineutrophil cytoplasmic antibodies
drug-induced vasculitis
leukocytoclastic vasculitis
minocycline
url http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=2;spage=214;epage=216;aulast=Kapur
work_keys_str_mv AT sunilkapur minocyclineinducedantineutrophilcytoplasmicantibodyassociatedvasculitisinchildren
AT jitendraoswal minocyclineinducedantineutrophilcytoplasmicantibodyassociatedvasculitisinchildren
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