An image-based assay to quantify changes in proliferation and viability upon drug treatment in 3D microenvironments

An image-based assay to quantify changes in proliferation and viability upon drug treatment in 3D microenvironments

Abstract Background Every biological experiment requires a choice of throughput balanced against physiological relevance. Most primary drug screens neglect critical parameters such as microenvironmental conditions, cell-cell heterogeneity, and specific readouts of cell fate for the sake of throughpu...

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Bibliographic Details
Main Authors: Vasanth S. Murali, Bo-Jui Chang, Reto Fiolka, Gaudenz Danuser, Murat Can Cobanoglu, Erik S. Welf
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Cancer
Subjects:
Drug screen
High throughput
Image analysis
Spheroid
Organoid
Cell fate
Online Access:http://link.springer.com/article/10.1186/s12885-019-5694-1

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http://link.springer.com/article/10.1186/s12885-019-5694-1

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