Novel monoclonal antibodies against thymidine kinase 1 and their potential use for the immunotargeting of lung, breast and colon cancer cells

Novel monoclonal antibodies against thymidine kinase 1 and their potential use for the immunotargeting of lung, breast and colon cancer cells

Abstract Background Thymidine kinase 1 (TK1) is a pyrimidine salvage pathway enzyme that is up-regulated in malignant tissues and elevated in the serum of cancer patients. While TK1 has been well established as a tumor biomarker, little has been done to explore its potential as a tumor target. Recen...

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Bibliographic Details
Main Authors: Edwin J. Velazquez, Taylor D. Brindley, Gajendra Shrestha, Eliza E. Bitter, Jordan D. Cress, Michelle H. Townsend, Bradford K. Berges, Richard A. Robison, K. Scott Weber, Kim L. O’Neill
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Cancer Cell International
Subjects:
Thymidine kinase 1
Tumor biomarker
Monoclonal antibody
ELISA
ADCC
Antibody-based therapies
Online Access:http://link.springer.com/article/10.1186/s12935-020-01198-8

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http://link.springer.com/article/10.1186/s12935-020-01198-8

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