Classical Swine Fever Virus Infection and Its NS4A Protein Expression Induce IL-8 Production through MAVS Signaling Pathway in Swine Umbilical Vein Endothelial Cells

Classical Swine Fever Virus Infection and Its NS4A Protein Expression Induce IL-8 Production through MAVS Signaling Pathway in Swine Umbilical Vein Endothelial Cells

Classical swine fever virus (CSFV) infection causes a severe disease of pigs, which is characterized by hemorrhage, disseminated intravascular coagulation, and leucopenia. IL-8, a main chemokine and activator of neutrophils, regulates the permeability of endothelium, which may be related to the hemo...

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Bibliographic Details
Main Authors: Wang Dong, Huifang Lv, Kangkang Guo, Tao Wang, Yueling Ouyang, Mingxing Jin, Yanming Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Microbiology
Subjects:
classical swine fever virus
NS4A
MAVS
ROS
IL-8
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.02687/full

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