Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system

A deterministic biologically based dose-response model for the thyroidal system in a near-term pregnant woman and the fetus was recently developed to evaluate quantitatively thyroid hormone perturbations. The current work focuses on conducting a quantitative global sensitivity analysis on this compl...

Full description

Bibliographic Details
Main Authors: Annie eLumen, Kevin eMcNally, Nysia eGeorge, Jeffrey W Fisher, George D Loizou
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00107/full