Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD

Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD

Abstract Background Beta cell identity changes occur in the islets of donors with diabetes, but the molecular basis of this remains unclear. Protecting residual functional beta cells from cell identity changes may be beneficial for patients with diabetes. Results A somatostatin-positive cell populat...

Full description

Bibliographic Details
Main Authors: Nicola Jeffery, David Chambers, Brandon M. Invergo, Ryan M. Ames, Lorna W. Harries
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Cell & Bioscience
Subjects:
Beta-cells
Cell differentiation
HNRNPD
RNA binding proteins
Online Access:https://doi.org/10.1186/s13578-021-00658-6

Internet

https://doi.org/10.1186/s13578-021-00658-6

Similar Items