Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface

Abstract Antibiotic efflux is one of the most critical mechanisms leading to bacterial multidrug resistance. Antibiotics are effluxed out of the bacterial cell by a tripartite efflux pump, a complex machinery comprised of outer membrane, periplasmic adaptor, and inner membrane protein components. Un...

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Bibliographic Details
Main Authors: Cesar A. López, Timothy Travers, Klaas M. Pos, Helen I. Zgurskaya, S. Gnanakaran
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-16497-w