Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface
Abstract Antibiotic efflux is one of the most critical mechanisms leading to bacterial multidrug resistance. Antibiotics are effluxed out of the bacterial cell by a tripartite efflux pump, a complex machinery comprised of outer membrane, periplasmic adaptor, and inner membrane protein components. Un...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-11-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-16497-w |